abstract：BACKGROUND AND AIM:A recent study in Indian subjects suggested common variants in apolipoprotein C3 (APOC3) (T-455C at rs2854116 and C-482T at rs2854117) to contribute to non-alcoholic fatty liver disease (NAFLD), plasma apoC3 and triglyceride concentrations. Our aim was to determine the contribution of genetic variati...

journal_title：Journal of gastroenterology and hepatology

authors： Hyysalo J,Stojkovic I,Kotronen A,Hakkarainen A,Sevastianova K,Makkonen J,Lundbom N,Rissanen A,Krauss RM,Melander O,Orho-Melander M,Yki-Järvinen H

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND AND AIM:We aimed to determine whether reflux- and symptom-related parameters can predict the efficacy of proton pump inhibitors (PPI) in non-erosive reflux disease (NERD). METHODS:Twenty-seven NERD patients who had experienced heartburn more than once a week within the previous month were enrolled. Intraeso...

journal_title：Journal of gastroenterology and hepatology

authors： Shimatani T,Sugimoto M,Nishino M,Adachi K,Furuta K,Ito M,Kurosawa S,Manabe N,Mannen K,Hongo M,Chiba T,Kinoshita Y,Acid-Related Symptom Research (ARS) Group.

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND AND AIM:Ecabet sodium is reported to have a bactericidal effect on Helicobacter pylori and inhibit urease activity in vitro. METHODS:Seven male volunteers (mean age, 51.3 years; range, 45-55 years) with H. pylori infection were medicated with 1 g ecabet sodium t.i.d. for 4 weeks. The urea breath test (UBT) ...

journal_title：Journal of gastroenterology and hepatology

authors： Okuda M,Yamamoto N,Fukuda N,Maekawa K,Kusaka T,Hashimoto M,Kotake J,Koizuka H,Fukuda Y

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND AND AIM:Application of acetic acid topically to the mucosal or serosal side of the stomach has been well used to create a chronic gastric ulcer model. The aim of the present study was to apply it as a new cytoreductive approach in a mouse model of gastric cancer. METHODS:A total of 43 genetically engineered...

journal_title：Journal of gastroenterology and hepatology

authors： Okabe S,Kodama Y,Cao H,Johannessen H,Zhao CM,Wang TC,Takahashi R,Chen D

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Colorectal laterally spreading tumors (LST) > 20 mm are usually treated by endoscopic submucosal dissection (ESD) or endoscopic mucosal resection (EMR). Endoscopic piecemeal mucosal resection (EPMR) is sometimes required. The aim of our study was to compare the outcomes of ESD and EMR, including EPM...

journal_title：Journal of gastroenterology and hepatology

authors： Terasaki M,Tanaka S,Oka S,Nakadoi K,Takata S,Kanao H,Yoshida S,Chayama K

更新日期：2012-04-01 00:00:00

abstract：:Gallbladder cancer (GBC) is the leading cause of cancer related mortality in certain geographic areas. Most of the patients with GBC have advanced disease at presentation, precluding curative resection resulting in a dismal prognosis. However, recent advances in the understanding of its epidemiology and pathogenesis c...

journal_title：Journal of gastroenterology and hepatology

authors： Dutta U

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND AND AIM:This study investigated whether diabetes mellitus (DM) increased the risk of pancreatic cancer and whether anti-diabetic drugs reduced the risk in Taiwan. METHODS:We designed a population-based cohort study using the Taiwan National Health Insurance Database, which consisted of 49,803 patients aged ...

journal_title：Journal of gastroenterology and hepatology

authors： Liao KF,Lai SW,Li CI,Chen WC

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Uncoupling protein-2 (UCP-2) is a negative regulator of reactive oxygen species (ROS) production. We investigated the effect of UCP-2 on disease progression in a murine dextran sodium sulfate (DSS)-induced colitis model, and the expression and distribution of tight junction (TJ) proteins, such as oc...

journal_title：Journal of gastroenterology and hepatology

authors： Zhang H,Kuai XY,Yu P,Lin L,Shi R

更新日期：2012-03-01 00:00:00

abstract：:There are approximately 277,000 new cases of pancreatic cancer and 266,000 deaths from pancreatic cancer annually, indicating a mortality rate of 96% of the cases diagnosed. Because of the ineffectiveness of therapies, a major emphasis needs to be placed on prevention. This paper reviews the epidemiology and risk fact...

journal_title：Journal of gastroenterology and hepatology

authors： Pandol S,Gukovskaya A,Edderkaoui M,Dawson D,Eibl G,Lugea A

更新日期：2012-03-01 00:00:00

abstract：:One of the characteristic features of the majority of pancreatic ductal adenocarcinomas is an abundant desmoplastic/stromal reaction. Until recently, this stroma had received little attention from researchers studying the pathogenesis of pancreatic cancer, with most of the research focus resting on the biology of tumo...

journal_title：Journal of gastroenterology and hepatology

authors： Apte MV,Wilson JS

更新日期：2012-03-01 00:00:00

abstract：:Cancer stem cells (CSC) have been identified in a growing number of human malignancies. CSC are functionally defined by their ability to self-renew and recapitulate tumors in the ectopic setting, and a growing number of studies have shown that they display other functional characteristics, such as invasion and drug re...

journal_title：Journal of gastroenterology and hepatology

authors： Rasheed ZA,Matsui W

更新日期：2012-03-01 00:00:00

abstract：:Gastrointestinal (GI) manifestations of leukemia occur in up to 25% of patients at autopsy, generally during relapse. Its presence varies with the type of leukemia and has been decreasing over time due to improved chemotherapy. Gross leukemic lesions are most common in the stomach, ileum, and proximal colon. Leukemia ...

journal_title：Journal of gastroenterology and hepatology

authors： Ebert EC,Hagspiel KD

更新日期：2012-03-01 00:00:00

abstract：:Low-dose aspirin (ASA) has emerged as one of the most important causes of peptic ulcer bleeding in developed countries. Among the risk factors of ASA-associated ulcer bleeding, Helicobacter pylori infection is one of the few that is treatable. Recent evidence showed that among patients with a history of ASA-associated...

journal_title：Journal of gastroenterology and hepatology

authors： Chan FK

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND AND AIM:Colonic mucosal defects might be a route for bacterial invasion into the portal system, with subsequent hematogenous spread to the liver. We retrospectively investigated the results of colonoscopy and the clinical characteristics of patients with pyogenic liver abscess of colonic origin. METHODS:A t...

journal_title：Journal of gastroenterology and hepatology

authors： Jeong SW,Jang JY,Lee TH,Kim HG,Hong SW,Park SH,Kim SG,Cheon YK,Kim YS,Cho YD,Kim JO,Kim BS,Lee EJ,Kim TH

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND AND AIM:Colorectal cancer (CRC) screening improves survival and requires appropriate recommendation by general practitioners (GPs). Screening practises may be influenced by barriers related to ethnicity and training. METHODS:A mail survey assessed GPs' practises and the barriers towards CRC screening. The a...

journal_title：Journal of gastroenterology and hepatology

authors： Koo JH,You MY,Liu K,Athureliya MD,Tang CW,Redmond DM,Connor SJ,Leong RW

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND AND AIM:Multiple diagnostic and therapeutic endoscopic ultrasound (EUS) procedures have been widely performed using a standard oblique-viewing (OV) curvilinear array (CLA) echoendoscope. Recently, a new, forward-viewing (FV) CLA was developed, with the advantages of improved endoscopic viewing and manipulati...

journal_title：Journal of gastroenterology and hepatology

authors： Iwashita T,Nakai Y,Lee JG,Park DH,Muthusamy VR,Chang KJ

更新日期：2012-02-01 00:00:00

abstract：:Despite a high prevalence of liver disease in Viet Nam, there has been no nationwide approach to the disease and no systematic screening of at-risk individuals. Risk factors include chronic hepatitis B (estimated prevalence of 12%), chronic hepatitis C (at least 2% prevalence), and heavy consumption of alcohol among m...

journal_title：Journal of gastroenterology and hepatology

authors： Gish RG,Bui TD,Nguyen CT,Nguyen DT,Tran HV,Tran DM,Trinh HN,International Group for Liver Health in Viet Nam.

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND AND AIM:As a newly identified subset of T helper cells, T-helper 17 cells (Th17) are major mediators of inflammation-associated disease. Some reports have revealed significantly increased Th17 cells in hepatitis B virus-infected patients, and a recent study has demonstrated that hepatitis C virus (HCV)-speci...

journal_title：Journal of gastroenterology and hepatology

authors： Chang Q,Wang YK,Zhao Q,Wang CZ,Hu YZ,Wu BY

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Balloon-occluded retrograde transvenous obliteration (B-RTO) is an effective treatment for gastric varices (GVx), as well as hepatic encephalopathy. The aim of this study was to examine the changes of the hepatic vein pressure gradient (HVPG) after B-RTO and determine the relation between the change...

journal_title：Journal of gastroenterology and hepatology

authors： Uehara H,Akahoshi T,Tomikawa M,Kinjo N,Hashimoto N,Nagao Y,Kamori M,Maehara Y

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND AND AIM:The technical performance of colonoscopy performed in deeply sedated patients differs from that performed without sedation or under minimal to moderate sedation. The aim of this study is to evaluate the factors affecting cecal intubation during colonoscopy performed under deep sedation. METHODS:A to...

journal_title：Journal of gastroenterology and hepatology

authors： Hsu CM,Lin WP,Su MY,Chiu CT,Ho YP,Chen PC

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND AND AIM:The major transporter responsible for bile acid uptake from the intestinal lumen is the apical sodium-dependent bile acid transporter (ASBT, SLC10A2). Analysis of the SLC10A2 gene has identified a variety of sequence variants including coding region single nucleotide polymorphisms (SNPs) that may inf...

journal_title：Journal of gastroenterology and hepatology

authors： Ho RH,Leake BF,Urquhart BL,Gregor JC,Dawson PA,Kim RB

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND AND AIM:Hepatocellular carcinoma (HCC) is the third most common reason for cancer-related death worldwide. Many countries either lack appropriate clinical practice guidelines for the diagnosis and treatment of HCC or the quality of their guidelines has never been evaluated. The main objective of our work was...

journal_title：Journal of gastroenterology and hepatology

authors： Schmidt S,Follmann M,Malek N,Manns MP,Greten TF

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND AND AIM:The aim of the present study was to evaluate the frequency of complications during endoscopic ultrasound (EUS)-guided drainage of pancreatic fluid collections (PFC), identify contributing factors, and report on management outcomes. METHODS:All patients who underwent EUS-guided PFC drainage over 7 ye...

journal_title：Journal of gastroenterology and hepatology

authors： Varadarajulu S,Christein JD,Wilcox CM

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND AND AIM:Same-day bidirectional endoscopy, including esophagogastroduodenoscopy (EGD) and colonoscopy, is frequently performed to screen for cancer and gastrointestinal bleeding. However, the optimal sequence for the procedures is unclear thus far. The aim of this study was to evaluate the optimal sequence fo...

journal_title：Journal of gastroenterology and hepatology

authors： Hsieh YH,Lin HJ,Tseng KC

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND AND AIM:As bacterial resistance to clarithromycin limits the efficacy of clarithromycin-based regimens for Helicobacter pylori infection, attention has turned to quinolone-based rescue therapies. Resistance of H. pylori to both clarithromycin and quinolone can be predicted by genetic testing. Here, we used t...

journal_title：Journal of gastroenterology and hepatology

authors： Yamade M,Sugimoto M,Uotani T,Nishino M,Kodaira C,Furuta T

更新日期：2011-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most commonly diagnosed malignancy of the liver and is the third most frequent cause of cancer death worldwide. Although advances in HCC detection and treatment have increased the likelihood of a cure at early stages of the disease, HCC remains largely incurable because of late pr...

journal_title：Journal of gastroenterology and hepatology

authors： Tong CM,Ma S,Guan XY

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND AND AIM:  The clinical utility of capsule endoscopy (CE) is often limited by incomplete small-bowel transit. The aim was to determine whether the use of an external real-time viewer could reduce delays caused by delayed gastric emptying of the capsule or delayed intestinal transit and also improve the rate o...

journal_title：Journal of gastroenterology and hepatology

authors： Shiotani A,Honda K,Kawakami M,Nishi R,Murao T,Ishii M,Matsumoto H,Kusunoki H,Hata J,Haruma K

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Both clinical outcomes and factors predictive for poor response after an initial course of corticosteroids have not yet been well established in the treatment of moderate to severe ulcerative colitis (UC). We therefore evaluated the short- and long-term effects of corticosteroids and prognostic fact...

journal_title：Journal of gastroenterology and hepatology

authors： Yoon JY,Cheon JH,Park JJ,Hong SP,Kim TI,Kim WH

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND AND AIM:The purpose of this study was to describe the computed tomography (CT) findings of sorafenib-treated hepatic tumors in patients with advanced hepatocellular carcinoma and to correlate the findings to the overall survival (OS). METHODS:Twenty-eight sorafenib-treated patients who had advanced hepatoce...

journal_title：Journal of gastroenterology and hepatology

authors： Kim MJ,Choi JI,Lee JS,Park JW

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND AND AIM:Fucosylated alpha-fetoprotein (AFP-L3) is known to be a marker of poor prognosis in patients with hepatocellular carcinoma (HCC). However, it has been difficult to measure AFP-L3 under low AFP (≤ 20 ng/mL). The aim of this study was to elucidate the role of AFP-L3 in HCC patients with low AFP conditi...

journal_title：Journal of gastroenterology and hepatology

authors： Nouso K,Kobayashi Y,Nakamura S,Kobayashi S,Takayama H,Toshimori J,Kuwaki K,Hagihara H,Onishi H,Miyake Y,Ikeda F,Shiraha H,Takaki A,Iwasaki Y,Kobashi H,Yamamoto K

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Interstitial cells of Cajal (ICCs), which express c-Kit receptor tyrosine kinase (KIT), play an important role in gastrointestinal motility. Loss of ICCs likely contributes to diabetic gastrointestinal motility disorder, however, the mechanism of attrition remains unknown. Here, we test the hypothesis that t...

journal_title：Journal of gastroenterology and hepatology

authors： Li Y,Kojima H,Fujino K,Matsumura K,Katagi M,Urabe H,Chan L,Eguchi Y,Zhao L,Kimura H

更新日期：2011-06-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is a major cause of hepatocellular carcinoma (HCC) and chronic liver disease worldwide. Recent developments and advances in HCV replication systems in vitro and in vivo, transgenic animal models, and gene expression profiling approaches have provided novel insights into the mechanisms...

journal_title：Journal of gastroenterology and hepatology

authors： Yamashita T,Honda M,Kaneko S

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Endoscopic resection (ER) has become an important therapeutic option for early gastric cancer (EGC). Some investigators have suggested that this indication should be extended. We aimed to compare the extended indication of ER for intramucosal EGC based on data from a large, single-center study. METHODS:We a...

journal_title：Journal of gastroenterology and hepatology

authors： Chung JW,Jung HY,Choi KD,Song HJ,Lee GH,Jang SJ,Park YS,Yook JH,Oh ST,Kim BS,Kim JH

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND AND AIM:The conventional method of anatomical right hemihepatectomy (ARHH) requires hilus dissection. We report a method without hilus dissection to minimize intraoperative bleeding. METHODS:We retrospectively evaluated data of 107 patients who received ARHH involving ligation of corresponding inflow and ou...

journal_title：Journal of gastroenterology and hepatology

authors： Chen XP,Zhang ZW,Huang ZY,Chen YF,Zhang WG,Qiu FZ

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVES:The epidemiology of lower gastrointestinal bleeding (LGIB) in Western populations has been reported; however, there are scant Asian reports. The aim of the present study was to determine the etiology of LGIB in a Chinese population by reporting a retrospective case series and a systematic analysis of Chinese...

journal_title：Journal of gastroenterology and hepatology

authors： Bai Y,Peng J,Gao J,Zou DW,Li ZS

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND AND AIM:According to the Rome III definition, irritable bowel syndrome (IBS) has been a biopsychosocial dysfunction. We tried to know whether the IBS clinical manifestations were comparable to other countries. METHOD:We have reviewed the IBS publications in Taiwan, thus its clinical significances are summar...

journal_title：Journal of gastroenterology and hepatology

authors： Chang FY,Lu CL

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE AND BACKGROUND:The role of psychological disturbance in the pathogenesis of functional dyspepsia is uncertain. We aimed to examine for differences in anxiety, depression and health-related quality of life (HRQOL) between adults with organic (OD) and functional dyspepsia (FD). METHODOLOGY:A prospective, cross...

journal_title：Journal of gastroenterology and hepatology

authors： Mahadeva S,Goh KL

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND AND AIM:We aimed to validate the non-invasive criteria for the characterization of portal vein thrombosis (PVT) in patients with cirrhosis and hepatocellular carcinoma (HCC). In a prospective study, we examined the impact of arterial hypervascularity, as established by the European Association for the Study ...

journal_title：Journal of gastroenterology and hepatology

authors： Sorrentino P,Tarantino L,D'Angelo S,Terracciano L,Ferbo U,Bracigliano A,Panico L,De Chiara G,Lepore M,De Stefano N,Fiorentino F,Vecchione R

更新日期：2011-04-01 00:00:00

abstract：:Functional gastrointestinal disorders (FGIDs) are common in clinical practice and in communities around the world, including Korea. In a recent point prevalence study on functional dyspepsia (FD) in Korea using the Rome III criteria, 13.4% of community respondents reported dyspepsia. Forty-seven percent of these FD ca...

journal_title：Journal of gastroenterology and hepatology

authors： Park H

更新日期：2011-04-01 00:00:00

abstract：:Chronic pancreatitis (CP) is a disease characterized by irreversible destruction and fibrosis of the parenchyma, leading to pancreatic exocrine insufficiency. In developed countries, the etiology for 60% to 70% of CP amongst male patients is alcohol and 25% are classified as idiopathic chronic pancreatitis (ICP). The ...

journal_title：Journal of gastroenterology and hepatology

authors： Reddy DN,Prasad SS

更新日期：2011-03-01 00:00:00